- Compartmentalized pressure in tumor cells
Petrie et al. show that inhibiting matrix metalloproteinases during 3D tumor cell migration activates the fibroblast-associated nuclear piston mechanism of intracellular pressure generation to slow tumor cell movement.
- Physical regulation of B cell antigen extraction
To mount antibody responses, B cells need to extract antigens from antigen-presenting cells (APCs). Using new DNA nanosensors, Spillane and Tolar show that B cell antigen extraction occurs via mechanical forces and is regulated by physical properties of the APCs.
- Interrogating cell signal perception with optogenetics
In this Viewpoint article, Wendell A. Lim and colleagues examine the ways by which optogenetic tools and techniques are being used to query cellular signaling and function.
- Δψ-mediated mitochondrial translocation
Schendzielorz et al. report that mitochondrial precursors display different dependencies on the membrane potential (Δψ) for translocation. Two distinct Δψ-dependent steps promote precursor translocation, the first driving presequence translocation and the second acting on the mature portion of the polypeptide chain.