- CLUH regulates transcripts of metabolic enzymes
CLUH binds mRNAs implicated in intermediate metabolism and oxidative phosphorylation, but the physiological and molecular significance of these interactions is unclear. Schatton et al. use new constitutive and liver-specific Cluh knockouts to define the function of CLUH in catabolic and energy-converting pathways as a regulator of the translation and stability of target mRNAs.
- Regulation of hepatic bioenergetics by HSF1
How cells sense energetic demands and regulate their bioenergetic networks to balance anabolism and catabolism is unclear. Qiao et al show that HSF1, a regulator of the chaperone response, has a central role in systemic energy sensing and is required for metabolic adaptation to nutrient availability.
- VDAC2–BAK axis permeabilizes peroxisome membrane
VDAC2 controls the stable localization of BAK to mitochondria and its ability to mediate mitochondrial outer membrane permeabilization. Hosoi et al. now report that BAK shifts from mitochondria to peroxisomes under VDAC2-deficient conditions, giving rise to the mislocalization of peroxisomal matrix proteins such as catalase, which suggests that BAK can also regulate the permeability of peroxisomal membranes.
- Trafficking of integral membrane proteins to cilia
Trafficking of integral membrane proteins to cilia is poorly understood. Badgandi et al. show that tubby family proteins TULP3 and TUB act as general adapters for ciliary trafficking of structurally diverse integral membrane cargo like GCPRs and the polycystin 1/2 complex.
- mTORC2 activity localization in cells
mTORC2 integrates extracellular cues with pathways controlling growth and proliferation, but the spatial control of mTORC2 activity is unclear. Using a new reporter, Ebner et al. show that endogenous mTORC2 activity localizes to plasma membrane, mitochondrial, and endosomal pools, which display distinct sensitivity to growth factors.
- HAP2/GCS1 is a gamete fusion protein
HAP2/GCS1 is essential for gamete fusion in plants, invertebrates, and protists. Valansi et al. demonstrate that a plant HAP2 is an authentic fusion protein that can fuse animal cells.
- Cardiolipin rescues PINK1 deficiency
Parkinson’s disease–causing mutations in PINK1 yield mitochondrial defects including inefficient electron transport between complex I and ubiquinone. Vos et al. show that genetic and pharmacological inhibition of fatty acid synthase bypass these complex I defects in fly, mouse, and human Parkinson’s disease models.