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<![CDATA[Keratins and protein synthesis: the plot thickens]]>
http://jcb.rupress.org/cgi/content/short/187/2/157?rss=1
In addition to protecting epithelial cells from mechanical stress, keratins regulate cytoarchitecture, cell growth, proliferation, apoptosis, and organelle transport. In this issue, Vijayaraj et al. (2009. J. Cell Biol. doi:10.1083/jcb.200906094) expand our understanding of how keratin proteins participate in the regulation of protein synthesis through their analysis of mice lacking the entire type II keratin gene cluster.
]]>Mon, 19 Oct 2009 10:02:31 PDTinfo:doi/10.1083/jcb.200909134The Rockefeller University Presshw_mjid:jcb;187/2/15721871592009-10-19157Comments<![CDATA[It takes two to tango to the melanosome]]>
http://jcb.rupress.org/cgi/content/short/187/2/161?rss=1
The role of clathrin adaptor proteins in sorting cargo in the biosynthetic and recycling routes is an area of intense research. In this issue, Delevoye et al. (2009. J. Cell Biol. doi:10.1083/jcb.200907122) show that a close interaction between the clathrin adaptor AP-1 and a kinesin motor KIF13A is essential for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes and for organelle biogenesis.
]]>Mon, 19 Oct 2009 10:02:31 PDTinfo:doi/10.1083/jcb.200909100The Rockefeller University Presshw_mjid:jcb;187/2/16121871632009-10-19161Comments