Latest Articles http://jcb.rupress.org JCB RSS Feed -- Latest Articles 1540-8140 The Journal of Cell Biology 0021-9525 The Journal of Cell Biology http://jcb.rupress.org/icons/banner/title.gif http://jcb.rupress.org <![CDATA[Eukaryotic systems broaden the scope of synthetic biology]]> http://jcb.rupress.org/cgi/content/short/jcb.200908138v1?rss=1 Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological "devices" that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology have sprung from foundational work in bacteria. Designing synthetic circuits to operate reliably in the context of differentiating and morphologically complex cells presents unique challenges and opportunities for progress in the field. This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.

]]> Mon, 23 Nov 2009 15:05:26 PST info:doi/10.1083/jcb.200908138 The Rockefeller University Press hw_mjid:jcb;jcb.200908138v1 2009-11-23 Review <![CDATA[New PI(4,5)P2- and membrane proximal integrin-binding motifs in the talin head control {beta}3-integrin clustering]]> http://jcb.rupress.org/cgi/content/short/jcb.200908134v1?rss=1 A talin intermolecular interaction autoinhibits its own activation and regulates β3-integrin binding. When bound, β3-integrin undergoes structural alterations that prevent its β and subunits from associating, maintaining β3-integrin's clustering capability.

]]> Mon, 23 Nov 2009 15:05:25 PST info:doi/10.1083/jcb.200908134 The Rockefeller University Press hw_mjid:jcb;jcb.200908134v1 2009-11-23 Articles <![CDATA[Centrosomal Aki1 and cohesin function in separase-regulated centriole disengagement]]> http://jcb.rupress.org/cgi/content/short/jcb.200906019v1?rss=1 Cohesin subunit Scc1 and Akt kinase–interacting protein 1 both localize to centrosomes and regulate the timing of centriole separation during mitosis.

]]> Mon, 23 Nov 2009 15:05:23 PST info:doi/10.1083/jcb.200906019 The Rockefeller University Press hw_mjid:jcb;jcb.200906019v1 2009-11-23 Reports <![CDATA[{delta}-EF1 is a negative regulator of Ihh in the developing growth plate]]> http://jcb.rupress.org/cgi/content/short/jcb.200904034v1?rss=1 Hedgehog protein IHH expression is regulated by transcription factor -EF1 to control endochondral bone formation

]]> Mon, 23 Nov 2009 15:05:22 PST info:doi/10.1083/jcb.200904034 The Rockefeller University Press hw_mjid:jcb;jcb.200904034v1 2009-11-23 Articles <![CDATA[Kinesin 9 family members perform separate functions in the trypanosome flagellum]]> http://jcb.rupress.org/cgi/content/short/jcb.200903139v1?rss=1 KIF9B localizes to the axoneme and basal body and is needed for flagella assembly, whereas KIF9A localizes only to the axoneme and controls flagella motility without affecting their structure.

]]> Mon, 23 Nov 2009 15:05:28 PST info:doi/10.1083/jcb.200903139 The Rockefeller University Press hw_mjid:jcb;jcb.200903139v1 2009-11-23 Reports <![CDATA[Aki1 helps centrioles stay tight]]> http://jcb.rupress.org/cgi/content/short/jcb.1875iti1v1?rss=1 Mon, 23 Nov 2009 15:05:29 PST info:doi/10.1083/jcb.1875iti1 The Rockefeller University Press hw_mjid:jcb;jcb.1875iti1v1 2009-11-23 In This Issue