Latest Articles

Journeys through the Golgi--taking stock in a new era

Tue, 10 Nov 2009 13:38:18 PST

The Golgi apparatus is essential for protein sorting and transport. Many researchers have long been fascinated with the form and function of this organelle. Yet, despite decades of scrutiny, the mechanisms by which proteins are transported across the Golgi remain controversial. At a recent meeting, many prominent Golgi researchers assembled to critically evaluate the core issues in the field. This report presents the outcome of their discussions and highlights the key open questions that will help guide the field into a new era.

Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response

Schuck, S., Prinz, W. A., Thorn, K. S., Voss, C., Walter, P. — Tue, 10 Nov 2009 13:38:17 PST

Spermatogonial stem cells have an innate ability to choose, with constant probability, between different fates independently of cues from the microenvironment.

Capacity for stochastic self-renewal and differentiation in mammalian spermatogonial stem cells

Tue, 10 Nov 2009 13:38:15 PST

Spermatogonial stem cells have an innate ability to choose—with constant probability—between different fates, independently of cues from the microenvironment.

A dual function for Pex3p in peroxisome formation and inheritance

Munck, J. M., Motley, A. M., Nuttall, J. M., Hettema, E. H. — Tue, 10 Nov 2009 13:38:14 PST

Pex3p interacts with peroxisome retention factor Inp1p at the peroxisomal membrane, and functions in the organelle’s segregation in addition to its biogenesis.

Cohesinopathy mutations disrupt the subnuclear organization of chromatin

Tue, 10 Nov 2009 13:38:12 PST

Nuclear morphology, chromosomal condensation, and transcriptional-mediated localization of genes to the nuclear periphery are disturbed by mutations in cohesin pathway genes.

Drosophila glypicans regulate the germline stem cell niche

Hayashi, Y., Kobayashi, S., Nakato, H. — Tue, 10 Nov 2009 13:38:10 PST

Heparan sulfate glycoproteins dally and dally-like define the germ cell niche in female and male Drosophila, respectively.

Sizing up the ER stress response

Short, B. — Mon, 09 Nov 2009 08:50:22 PST

Germ cells decide for themselves

Short, B. — Mon, 09 Nov 2009 08:50:22 PST

Cohesin pathway makes the necessary arrangements

Short, B. — Mon, 09 Nov 2009 08:50:21 PST